Abstract
Arterial concentrations of given norepinephrine (NE) were measured after bolus administration in dogs with normal lungs and in those with oleic acid-induced lung edema. In both groups, the peak NE concentration was given by blood samples taken 30 sec after injection and the concentration showed a decreasing tendency thereafter. NE concentrations were always greater in the lung edema group than in the control group and a longer period was needed for NE concentrations to return to the baseline level. This delay in the clearance of NE from the circulation might reflect a diminished uptake by the pulmonary endothelium. This phenomenon may be used for the diagnosis of pulmonary endothelial injury.
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