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Abstract
Background. Failure of anti-Helicobacter therapy is the result noncompliance and resistance to the prescribed antibiotics. Aim. Antibiotic susceptibility of H. pylori was determined in native Dutch patients and patients of Turkish descent. Methods. In a period of eight years a total of 925 strains of H. pylori were cultured. Bacterial susceptibility was successfully determined in 746 (80.6%) of these isolates. Three hundred and nine strains (33%) originated from patients of Turkish descent. Results. In total clarithromycin resistance was found in 146 (20.5%) strains, metronidazole resistance in 147 (19.9%) strains. Amoxicillin resistance was found to be present in five strains. There is a slight but nonsignificant decrease in the percentage of clarithromycin-resistant strains in the consecutive period of eight years from 20% to 18%. No changes were seen in the consecutive years in metronidazole resistance. The number of clarithromycin-resistant strains decreased in Turkish patients, not in native Dutch patients. Conclusion. Resistance did not change significantly in consecutive years. But clinicians should take not only the antibiotic history into account but also ethnicity before prescribing metronidazole or clarithromycin.
Highlights
The discovery of H. pylori and the recognition of its clinical importance have been a major breakthrough in clinical medicine
In a previous study from our group it was shown that the resistance of H. pylori to clarithromycin rose in consecutive years while resistance to metronidazole showed a slight decrease [2]
The resistance of H. pylori to antibiotics is the main factor affecting the efficacy of the current regimens
Summary
The discovery of H. pylori and the recognition of its clinical importance have been a major breakthrough in clinical medicine. Failure of therapy is the result of noncompliance and of resistance of the bacterium to the prescribed antibiotics. In a previous study from our group it was shown that the resistance of H. pylori to clarithromycin rose in consecutive years while resistance to metronidazole showed a slight decrease [2]. Failure of anti-Helicobacter therapy is the result noncompliance and resistance to the prescribed antibiotics. Aim. Antibiotic susceptibility of H. pylori was determined in native Dutch patients and patients of Turkish descent. There is a slight but nonsignificant decrease in the percentage of clarithromycin-resistant strains in the consecutive period of eight years from 20% to 18%. The number of clarithromycin-resistant strains decreased in Turkish patients, not in native Dutch patients. Clinicians should take the antibiotic history into account and ethnicity before prescribing metronidazole or clarithromycin
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