Abstract
To evaluate correlations between changes in anti-U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years. Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index. All 9 major disease exacerbations were associated with peaks in anti-U1 RNA antibody level. These results seem to indicate that measuring anti-U1 RNA antibody levels can be useful for monitoring disease activity.
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