Changes in Anterior Chamber Parameters Measured by Pentacam in Coronavirus Disease 2019 Infection: A Longitudinal Study.

Saeed Shokoohi-Rad,Mojtaba Abrishami,Hamid-Reza Heidarzadeh,Elham Bakhtiari,Asma Payandeh,Alessandro Meduri

doi:10.1155/2022/6828924

Saeed Shokoohi-Rad, Mojtaba Abrishami + Show 4 more

Open Access

https://doi.org/10.1155/2022/6828924

Copy DOI

Abstract

Purpose To evaluate changes in anterior segment parameters measured by imaging in coronavirus disease 2019 (COVID-19) infection. Methods This longitudinal observational study included patients who recovered from COVID-19. All subjects exhibited a confirmed diagnosis of COVID-19 with a positive result of nasopharyngeal reverse transcription-polymerase chain reaction evaluation. Corneal Pentacam (Oculus, Dutenhofen, Germany) imaging was performed at least two weeks after recovery from systemic COVID-19. Measurements were repeated one and three months later. Results A total of 20 patients, 11 (55%) of whom were females, with a mean age of 35.5 ± 7.1 years (age range: 25–51 years) recovered from nonhospitalized COVID-19 infection, were enrolled in this study. An increase in the keratometry mean front, keratometry mean back, cornea volume, and anterior chamber depth was observed in the longitudinal evaluation; however, they showed no statistical significance. The anterior chamber volume was statistically increased at three-month follow-up, compared to baseline (baseline: 177.8 ± 36.68 mm3; three months: 182.25 ± 39.58 mm3, P=0.048). Conclusion COVID-19 infection may affect the cornea and anterior segment.

Highlights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of unusual pneumonia with multiorgan damage worldwide [1]
E presence of SARS-CoV-2 RNA and proteins was reported in the anterior chamber and corneal tissue following COVID-19 infection [10–13]
In posterior segment evaluations up to now, retinal thickness and vasculature have been affected in COVID-19 patients more than finding SARS-CoV-2 in retinal samples

Summary

Introduction

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of unusual pneumonia with multiorgan damage worldwide [1]. As well as corneal signs and symptoms, was reported, and the most prevalent manifestations were conjunctivitis and dry eye [2, 3]. E presence of SARS-CoV-2 RNA and proteins was reported in the anterior chamber and corneal tissue following COVID-19 infection [10–13]. The long-term effects of COVID-19 infection on the anterior segment parameters and cornea are unclear. In posterior segment evaluations up to now, retinal thickness and vasculature have been affected in COVID-19 patients more than finding SARS-CoV-2 in retinal samples. A case-control study on 31 patients recovered from COVID-19 infection reported decreased vessel density in the superficial and deep retinal capillary plexus in the foveal and parafoveal regions [15]. This study aimed to evaluate the Pentacam parameters of the anterior segment and cornea to investigate the hypotheses of anterior segment changes secondary to uvea changes in COVID-19 infection

Study Population

Imaging Procedures

Ethical Considerations

Results