Abstract
BackgroundVaccination against hemorrhagic fever with renal syndrome (HFRS) has been applied successfully for more than 20 years in China, and since 2008, the government has implemented the Expanded Program of Immunization (EPI) in regions with high incidence. In this study, we analyzed the EPI-related changes in age distribution in reported cases of HFRS and proposed new recommendations for prevention and control of the disease.MethodsData relating to incidence of HFRS, geographical location and age distribution were collected through the China Information System for Disease Control and Prevention (CISDCP) from 2005 to 2010. Excel and SPSS 18.0 software, χ2 tests and descriptive methodology were used for analysis of the data.ResultsA total 75 434 HFRS cases were reported in 28 provinces in China between 2005 and 2010. The majority of HFRS cases occurred in adults aged 30 to 55 and this group accounted for 68.3% of the total. With the implementation of the immunization program, HFRS age distribution has clearly changed in recent years. The proportion of HFRS cases among individuals targeted by EPI (16–60 years of age) decreased from 86.9% in 2005 to 81.9% in 2010. However, the proportion of cases among the non-vaccinated group aged <16 and >60 had increased from 13.1% in 2005 to 18.1% in 2010. Notably, in the >60 age group the proportion rose from 8.8% in 2005 to 14.7% in 2010. These differences were statistically significant.ConclusionHFRS vaccination has played an important role in HFRS control and prevention in China. However, since the proportion of HFRS cases over 60 years old has increased significantly since EPI was implemented, it is recommended that the age limit for vaccination be reconsidered. This finding may have practical implications for more effective HFRS vaccination in the future.
Highlights
Vaccination against hemorrhagic fever with renal syndrome (HFRS) has been applied successfully for more than 20 years in China, and since 2008, the government has implemented the Expanded Program of Immunization (EPI) in regions with high incidence
As the number of cases among the 16 to 60 age group accounted for more than 80 percent of the total [13,14], and because the Pharmacopoeia of People’s Republic of China (2005) [15] specified that the vaccines could only be used in persons between 16 and 60 years old, the program focused on this age group [16]
The HFRS cases were diagnosed in the hospital or the local CDC according to the Diagnostic Criteria for Epidemic Hemorrhagic Fever
Summary
Vaccination against hemorrhagic fever with renal syndrome (HFRS) has been applied successfully for more than 20 years in China, and since 2008, the government has implemented the Expanded Program of Immunization (EPI) in regions with high incidence. Aimed at two species of Hantavirus (HTNV and SEOV), a safe and effective bivalent HFRS vaccine was developed in the 1990s [8] and has been successfully applied [9,10,11,12]. In 2008, the HFRS-targeted Expanded Program on Immunization (EPI) was implemented by the Chinese Central Government in order to reduce the HFRS incidence further. In 2009, HFRS rates were found to have significantly decreased in EPI regions, and the vaccinationbased program was further expanded to 10 other provinces: Hunan, Jiangxi, Inner Mongolia, Hubei, Henan, Jiangsu, Fujian, Anhui, Sichuan and Guangdong. The bivalent HFRS vaccine is considered safe for other age groups [10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
