Abstract
Experiments on rats showed that the self-stimulation (SS) response reduces the increase in the 11-hydroxycorticosteroid (11-HCS) concentration in blood after electrical nociceptive stimulation (ENS) of the limbs. Diazepam (1 mg/kg) reduced the liberation of 11-HCS and the β-lipoprotein concentration in response to SS and ENS and raised the phospholipid concentration. Diazepam and preliminary ENS evoked activation of SS. It is concluded that diazepam and activation of the positive reinforcement system act in the same direction with respect to 11-HCS excretion and the changes in lipid metabolism during ENS.
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