Abstract
Changes in enzyme activity due to <i>in vivo</i> dusting with quartz were investigated in guinea-pig lungs before the formation of collagen. Of the three enzymes investigated, succindehydrogenase and succinoxidase are increased, and cytochrome c oxidase is not affected by inhalation of quartz dust. The increases tend to reach a maximum which is more rapidly approached by succindehydrogenase than by succinoxidase. The results are discussed in relation to results obtained by other workers on the <i>in vitro</i> effects of silicon compounds. The lung weight increased markedly with increased period of inhalation of dust. This increase is discussed in relation to fat and ash content.
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