Abstract
To clarify the effects of organic solvents on the central nervous system (CNS), we exposed rats to toluene or n-hexane gas or a mixture of the two compounds at 1000–8000 ppm for 8 h, and measured acetylcholine (ACh) content, choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities in homogenized rat hippocampus. ACh was increased at low concentrations of the solvents, but was markedly reduced at high concentrations. ChAT activity was significantly reduced at high concentrations of solvent mixtures. AChE activity was increased by solvents. We concluded that both the decrease in ChAT activity and the increase in AChE activity were the cause of the decrease in ACh content.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
