Changes in 25 hydroxyvitamin D level in school-aged children with orthostatic hypertension

Abstract

Objective To explore the change in 25 hydroxyvitamin D[25-(OH)D] level in school-aged children with orthostatic hypertension (OHT). Methods Nineteen cases of school-aged children with OHT confirmed diagnosis by head-up tilt table test at the Department of Pediatric Cardiovasology, Children′s Medical Center, the Second Xiangya Hospital, Central South University, from October 2014 to February 2017, were selected as OHT group, including 17 males and 2 females, and their ages were from 7 to 14(11.21±2.70) years old.Nineteen healthy children including 17 males and 2 females and aged 8 to 14(11.05±2.35) years old who had a healthy examination of child care at the hospital in the same period were selected as healthy control group.In two groups of children all possible basic diseases were eliminated, such as severe liver and kidney disease, abnormal thyroid function and metabolic bone disease and/or the long-term use of 25-(OH)D metabolism drugs, accepted the serum 25-(OH) D detection. Results (1)There was no significant difference in age and gender between the OHT group and the healthy control group(t=0.559, P>0.05; χ2=0.000, P>0.05). The 25-(OH)D levels were significantly lower in the OHT group than those in the healthy control group [(39.62±10.65) nmol/L vs.(64.83±10.28) nmol/L, t=-7.422, P 0.05). Taking 25-(OH)D level as dependent variable, age, gender, height, body mass, systolic pressure, diastolic blood pressure as independent variables, multiple stepwise regression equation to predict 25-(OH)D level was not fit. Conclusion Lower level of 25-(OH)D may be one of the mechanisms for the onset of the school-aged children with OHT. Key words: 25 hydroxyvitamin D; School-aged children; Orthostatic hypertension