Abstract
1. Early weaning in piglets is associated with changes in dopamine metabolism in the caudate nucleus. In particular, a decrease in the amount of the enzyme tyrosine hydroxylase was observed. 2. An analysis of the kinetic properties of tyrosine hydroxylase from the caudate nucleus of early-weaned piglets shows that there is a relative increase in the activity of the enzyme which may indicate a mechanism compensating for the decreased amount of enzyme. 3. The increase in activity is mediated through a decrease in the K m for tetrahydrobiopterin and is reversed, in vitro, when the tissue is homogenized at pH values greater than 8.0.
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