Changes and significance of serum S-100 protein and B/A ratio in neonates with hyperbilirubinemia

Abstract

Objective To evaluate the significance of S-100 protein and B/A for early predicting the brain damage caused by neonatal hyperbilirubinemia. Methods According to the gestational age, birth weight and the intervention criterion of neonatal jaundice,84 newborns were divided into 4 groups. Group A (n =22) were term infants with unconjugated hyperbilirubinemia. Group B( n = 22) were control group of term infants. Group C ( n = 20 ) were premature newborns with unconjugated hyperbilirubinemia. Group D ( n = 20) were premature control group. We detected their serum levels of S-100, total bilirubin (TBC), albumin and calculated B/A ratio. Results The S-100 level and B/A ratio of hyperbilirubinemia group were significantly higher than those of control group in term infants [group A(0. 36±0. 14)μg/L vs group B (0. 25±0. 07)μg/L,P＜0.05)and premature newborns (group C(0.40±0.09) μg/L vs group D(0.28±0.05)μg/L,P ＜0.05) ].There was positive correlation between level of serum S-100 and B/A ratio in hyperbilirubinemia group of terminfants (r =0. 509,P＜0. 05). Conclusion Serum S-100 protein and B/A ratio may be a sensitive indicators for early predicting bilirubinic toxicity. Key words: S-100 protein; Hyperbilirubinemia; Albumin; Brain damage; Infant,newborn