Changes and significance of serum dust mite specific immunoglobulin G4 in dust mite allergic asthma

Abstract

Objective To explore the pathogenesis of respiratory inflammation in allergic asthma and investigate the most effective evaluation of therapeutic efficiency by observing the serum level of specific immunoglobulin G4 (sIgG4). Methods 65 patients with allergic asthma from September 2015 to September 2016 in the Second Affiliated Hospital of Fujian Medical University were selected with acute attacks from mild to moderate degree (Asthma Control Test score 20 points). Another 30 healthy subjects were chosen as control group.Measure and compare the serum sIgG4, total immunoglobulin E (TIgE), and also forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF), skin prick test, eosinophils (EOS), fractional of exhaled nitric oxide (FeNO) in acute attack stage of asthma group, remission stage of asthma group and control group. Results Serum sIgG4, TIgE, sIgG4/TIgE were higher in remission stage of asthma group and acute attack stage of asthma group than control group (F=112.93, 42.826, 4.092, all P<0.05). The levels of sIgG4 and sIgG4/TIgE in remission stage of asthma group were higher than those in acute attack stage of asthma group, TIgE was lower in acute attack stage of asthma group (t=-11.446, 7.750, -2.444, all P<0.05). The levels of FEV1, PEF, FeNO and EOS in remission stage of asthma group were significantly better than those in acute attack stage of asthma group, and the differences were statistically significant (t=15.044, 11.744, 22.202, 11.645, all P<0.001). Conclusions sIgG4 can indirectly reflect the respiratory inflammation in dust mite allergic asthma and have monitoring and treatment guiding value on them. Key words: Asthma; Specific imumunoglobulin G4; Respiratory function test; Clinical effect