Changes and clinical significance of ischemic modified albumin in patients with polycystic ovary syndrome

Abstract

Objective To investigate the change of ischemia modified albumin (IMA) in polycystic ovary syndrome (PCOS) women, and to examine the relationship between IMA and metabolic disorder. Methods 31 PCOS women (PCOS group) and 28 age- and BMI-matched healthy women (control group) were recruited. Serum IMA levels and related biochemical indexes were compared between the two groups, and the correlation between IMA and each index was analyzed. Results Serum IMA level in PCOS group was significantly higher than that in the control group (P<0.05) . Correlation analysis showed that serum IMA levels were positively correlated with testosterone levels (r=0.57, P=0.03) . Conclusion Serum IMA levels in PCOS patients are significantly elevated and closely related to testosterone, suggesting that oxidative stress may be involved in the pathogenesis and development of hyperandrogenemia. Key words: PCOS; IMA; Oxidative stress; Hyperandrogenemia