Changed Resting-State Brain Signal in Parkinson's Patients With Mild Depression.

Min Wang,Yuheng Zi,Sainan Cai,Haiyan Liao,Qin Shen,Yijuan Xiang,Hongchun Zhang,Changlian Tan,Tianyu Wang,Siyu Liu,Zhenni Mao

doi:10.3389/fneur.2020.00028

Abstract

Background: Depression is reported to occur 5–10 years early than the onset of motor symptoms in Parkinson (PD) patients. However, markers for early diagnosis of PD in individuals with sub-clinical depression still remain to be identified.Purpose: This study utilized Regional Homogeneity (ReHo) to investigate the alterations in resting state brain activities in Parkinson (PD) patients with different degrees of depression.Methods: Twenty non-depressed PD patients, twenty mild to moderately depressed PD patients, and thirteen severely depressed PD patients were recruited. Hamilton Depression Scale (HDS) and the Beck Depression Inventory (BDI) were assessed depression. Resting-state functional magnetic resonance imaging (rs-MRI) was analyzed with ReHo.Results: PD patients with mild to moderate depression had decreased ReHo in the left dorsal anterior cingulate cortex when compared with PD patients without depression. PD patients with severe depression exhibited increased ReHo in the left inferior prefrontal gyrus and right orbitofrontal area when compared with PD patients with mild to moderate depression. ReHo values in the bilateral supplementary motor area (SMA) in PD patients with severe depression was also increased when compared with PD patients without depression.Conclusions: This study suggests that rs-MRI with ReHo analysis can detect early changes in brain function that associate with depression in PD patients, which could be biomarkers for early diagnosis and treatment of PD related depression.

Highlights

Parkinson’s disease (PD) is a common degenerative disease of the central nervous system with an incidence only secondary to Alzheimer’s disease [1]
This study investigated the alterations in resting state brain activities using Regional Homogeneity (ReHo) in PD patients with different degrees of depression and non-depression
MdPD patients showed decreased ReHo values in the left dorsal anterior cingulate cortex when compared with ndPD patients (Figure 1). sdPD patients showed significant increased ReHo values in the inferior prefrontal gyrus and right orbitofrontal area when compared to mdPD patients (Figure 2). sdPD patients showed increased ReHo in the bilateral supplementary motor area (SMA) when compared with ndPD patients (Figure 3 and Table 2)

Summary

Background

Depression is reported to occur 5–10 years early than the onset of motor symptoms in Parkinson (PD) patients. Markers for early diagnosis of PD in individuals with sub-clinical depression still remain to be identified. Purpose: This study utilized Regional Homogeneity (ReHo) to investigate the alterations in resting state brain activities in Parkinson (PD) patients with different degrees of depression

Methods

Results

Conclusions

INTRODUCTION

MATERIALS AND METHODS

RESULTS