Changed count of CD4+ T-lymphocytes in the bone marrow of aggressive CBA mice

Abstract

Enhanced immune response of aggressive CBA mice after 10 daily confrontations in sensory contact on day 4 after immunization with sheep red blood cells (5×108) is paralleled by an increase in the count of CD4+ T-cells in the bone marrow. Aggressive behavior, weight of the spleen, and count of CD4+ T-helpers in the bone marrow (which is increased only in aggressors with a history of at least 3 victories) are correlated. The effect of aggressive behavior on immunity can be caused by changes of the neurochemical status of the brain and determined by an increase in the CD4+ T-helper count.