CHANGEABLE AND UNCHANGEABLE RISK FACTORS AS PREDICTORS OF THE RELAPSED ATRIAL FIBRILLATION: PP.1.44

Abstract

It is assumed that the basic risk factors of the frequent relapse of atrial fibrillation (AF) are feminine gender and organic heart diseases. In this connection, it is important to estimate the impact of changeable and unchangeable risk factors on the development and the rate of relapse of AF. Objective: Investigate the impact of such factors as gender, smoking, the degree of arterial hypertension (AH), the corresponding coronary heart disease (CHD), the remoteness of AF, the way of restoration of the heart rhythm and the type of the following antirhythmical therapy (AT) on the relapse of AF. 52 patients with AH of 1–3 degree, I-III stage, that first emerged (n = 16) and paroxysmal AF (n = 36) were investigated. The mean age 58,70 ± 8,33 years, 56% of men, 44% of women, the length of AH 9,47 ± 9,21 years, anamnesis on AF 5,6 ± 5,2 years. The sinus rhythm (SR) is restored medicamentically (amiodaron, n = 38) or using cardioversion (n = 14). The anamnesis, antihypertensive and AT are estimated initially and after 6 month period. In order to maintain the SR all the patients got AT (amiodaron and beta blockers) as well as antihypertensive therapy aimed to reach the desired level of arterial pressure of less than 140/90 mmHg. Results: Irrespective of the gender and the way of restoration of the heart rhythm, the AF of 38 patients (73%) during 6 months period relapsed. According to multifactor discriminant analysis the combination of smoking (ð = 0,0021), degree of AH (ð = 0,0386), beta blockers treatment (ð = 0,0475) and remoteness of AF (ð = 0,0205) appeared to be reliably significant risk factors of the relapse of AF. The presence of CHD didn't influence the risk of the relapse of AF. Conclusions: The combination of smoking, duration of the preceding anamnesis of AF, noncompensated AH and AT type influences the relapse of AF among the patients with AH.