Abstract
Objective To study the change pattern for the expression of chemokine receptor 4 (CXCR4) in the lung tissue of rats with pulmonary oxygen toxicity.Methods Thirty SD rats were randomly divided into 6 groups:the control group,the 2 h pure oxygen exposure group (or simply the 2 h group),the 4 h pure oxygen exposure group (the 4 h group),the 6 h group,the 8 h group and the 10 h group,each consisting of 5 animals.Observations on pathological changes in the lung tissue and changes in the CXCR4 expression levels in the lung tissues of rats were performed by Western Blot,then,comparisons were made with those of the control group.Results Pathological detection indicated that stasis of blood,edema and hemorrhage in the alveolar and pulmonary interstitial tissue deteriorated with the extension of oxygen exposure time.The expression level of CXCR4 in the lung tissue increased with the extension of exposure within 8 hours,however,the levels of CXCR4 in the 10 h group decreased to some extent,as compared with that of the 8 h group.Conclusions Mter exposure to high pressure oxygen,lung damage occurred in pulmonary tissue of rats,with the change pattern basically identical to that of CXCR4. Key words: Chemokine receptor 4 ; Oxygen toxicity; Lung tissue ; Mice
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