Change over time in the treatment condition for patients with subacute myelo-optico-neuropathy in Japan

Abstract

Background: Subacute myelo-optico-neuropathy (SMON) is a severe neuro-degenerative disorder caused by poisoning due to oral administration of clioquinol. It is characterized by impaired vision, optic atrophy, subacute myelopathy, spasticity, and dysesthesia of lower limbs and trunk. In Japan, over 12,000 cases developed from 1950s to1970, so many patients are still suffering although we have no new patients. Annual medical examination for SMON patients has been carried out as a permanent state measure.