Change of the State of the Natural Antioxidant Barrier of a Body and Psychological Parameters in Patients Aged above 60.

Katarzyna Porzych,Marcin Porzych,Daria Kupczyk,Mirosława Szark-Eckardt,Beata Augustyńska,Kornelia Kędziora-Kornatowska,Magdalena Żyła,Rafał Bilski,Emilia Mikołajewska,Martyna Porzych

doi:10.1155/2017/6568501

Abstract

Background The goal of this study is to assess the natural antioxidant barrier of the organism and selected psychological aspects of the aging process in patients above 60 years old. Methods The study included a total of 52 patients aged above 60 (mean age 67 ± 3.4) and 32 healthy subjects (mean age 22 ± 3.4) as a control group. All patients underwent psychological assessment using Test of Attentional Performance version 2.3 (TAP 2.3, four subtests: alertness, cross-modal integration, neglect with central task, and working memory) and biochemical analysis of venous blood concerning values of the selected parameters of oxidative stress (HT, GSH, GPXOS, GPXRBC, GRRBC1, SODRBC1, MDARBC1, NO2−/NO3−, and CP). Results Disorders of attention were observed mainly in elderly people, but an assumption that elderly people have developed more efficient ways of working memory use than younger people may be true. Results showed the reduced effectiveness of the body's natural antioxidant barrier in elderly people. Moderate positive and negative correlations among parameters of oxidative stress and psychological parameters were observed in the control group. Discussion Intensification of the attention deficits and oxidative stress may be observed as one of the pathogenic factors of age-dependent diseases.

Highlights

Aging of the human body is a natural, complex, and longlasting physiological process
There were statistically significant differences observed between study group and control group in the “alertness” test
Reaction times were significantly shorter in the control group

Summary

Introduction

Aging of the human body is a natural, complex, and longlasting physiological process. It includes molecular changes both at the cellular level and at the level of the whole organism [1]. The goal of this study is to assess the natural antioxidant barrier of the organism and selected psychological aspects of the aging process in patients above 60 years old. All patients underwent psychological assessment using Test of Attentional Performance version 2.3 (TAP 2.3, four subtests: alertness, cross-modal integration, neglect with central task, and working memory) and biochemical analysis of venous blood concerning values of the selected parameters of oxidative stress (HT, GSH, GPXOS, GPXRBC, GRRBC1, SODRBC1, MDARBC1, NO2−/NO3−, and CP). Moderate positive and negative correlations among parameters of oxidative stress and psychological parameters were observed in the control group. Intensification of the attention deficits and oxidative stress may be observed as one of the pathogenic factors of age-dependent diseases

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Results

Conclusion