Abstract
Objective To investigate the bladder interstitial cells of Cajal (ICC) function in the pathogenesis of the diabetic cystopathy.Methods Fifty short hair Britain female guinea pigs were divided into two groups randomly,42 as the experiment group and the other 8 as the control group (group C).The experiment group was intraperitoneally injected with streptozotocin (STZ) to establish diabetic models.Diabetic guinea pigs were further divided into the decompensated bladder function group (namely DCP,group A) and compensated group (group B) by urodynamic study.Immunofluorescence staining,confocal laser microscope and transmission electron microscopy (TEM) technology were used to detect the morphology and ultrastructure changes of the ICC.Results The percentage of the ICC in group A was significantly lower than that of the group B and group C [(2.18 ± 0.04) ％ vs.(2.80 ± 0.05,2.81 ± 0.04) ％ respectively,P ＜0.01].Under the electron microscopic observation,the mitochondria in the ICC were reduced in the DCP group.The substrate also became less and shallow,and crest got shorter or even disappeared.Conclusion ICC may play an important role in the development of the DCP. Key words: Guinea pig; Diabetic Cystopathy; Interstitial cell of Cajal
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