Abstract
Single-nucleotide polymorphisms (SNPs) in the regulatory regions of human genes and, in particular, TATA boxes can alter the sensitivity to bacterial and viral infections and to drugs used for their treatment. These SNPs are associated with the risk of widespread multifactorial human diseases, such as arthritis, hypertension, cancer, Alzheimer’s disease, and others. Interaction of the TATA-binding protein (TBP) with TATA boxes on TATA-containing promoters nucleates the preinitiation complex assemblage, which is the initial stage of transcription regulation. This study considers the change of TBP affinity to the TATA boxes of human MBL, CYP 2A6, SOD1, and TPI genes bearing SNPs associated with autoimmune diseases, cardiovascular diseases, amyotrophic lateral sclerosis, neurodegenerative disorders, hypersensitivity to bacterial infections, etc. In all cases a decrease in the affinity of TBP to TATA-containing oligonucleotides was shown.
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