Change of serum inflammatory factors in cerebral hemorrhage patients after haematoma fluidify drainage operation

Abstract

Objective To study the change of inflammatory factors in cerebral hemorrhage patients after haematoma fluidify drainage operation and the recovery of neural function.Methods In the observe group,eightyone cases of hypertensive cerebral hemorrhage were treated by haematoma fluidify drainage operation through bore skull and tube placed through the entrance of rear forehead,eighty patients underwent conservative treatment at the same period were taken as controls.The bleeding quantities ranged from 15 to 30 ml in both groups.The observe group underwent operation within 6-24 hours.The neural-functional grade was observed and serum IL-6 ,TNF-a,CRP after the operation of 1,7,14,and 30 days were measured.Results On the 7th day after operation,the neural functional grade was 27.47 ±6.21 in the observed group,which was significantly lower than that of the control group (39.28 ±8.32) (P＜0.05).On the 14th and 30th day after operation,the neural functional grade in the observed group ( 19.14 ± 5.21,15.33 ± 4.47,respectively) were significantly lower than those of the control group (31.16 ±7.99,25.33 ± 5.55,respectively ) ( P ＜ 0.05 ) .The level of inflammation factor in the observe group was significantly lower than that in the control group on the 7th and 14th day after operation(P ＜0.01 and P ＜0.05,respectively) ,whereas on the 30th day there was no significant difference between the two groups(P ＞ 0.05).Conclusions The minimally invasive haematoma fluidify drainage operation can not only improve neural function,but also can reduce the product and release of inflammatory factors in the early stage of cerebral hemorrhage.It is helpful to protect the healthy cerebral tissue and other organs,therefore remarkably beneficial to the recovery and cure of cerebral hemorrhage. Key words: Cerebral hemorrhage; Minimally invasive; Haematoma fluidify drainage operation; Inflammatory factors