Change of renal function and its influencing factors in patients with acute coronary syndrome complicated with hypertension within 1 year after PCI

Abstract

Objective To analyze the change of renal function and its influencing factors in patients with acute coronary syndrome (ACS) complicated with hypertension within 1 year after percutaneous coronary intervention (PCI). Methods A total of 150 cases of ST segment elevation or non-ST segment elevation ACS complicated with hypertension were enrolled in the study. All patients were followed up for 1 year after PCI. According to the change of glomerular filtration rate (eGFR) 1 year after PCI, the subjects were divided into eGFR decrease group (n=82) and eGFR maintenance group (n=68). The differences in demographic data, complications, laboratory indicators, and intervention between the two groups were statistically analyzed, and univariate Logistic regression analysis was performed. Results Age, diastolic blood pressure, systolic blood pressure, and blood uric acid levels in the eGFR decrease group were significantly higher than those in the eGFR maintenance group (P 0.05). Non-conditional Logistic regression analysis showed that advanced age, high diastolic and systolic blood pressure, history of renal function damage, ST segment elevation ACS, high blood uric acid level, and emergency PCI were significantly correlated with change of renal function within 1 year after PCI (P<0.05). Conclusions Patients with ACS complicated with hypertension are prone to have renal function damage after PCI, and the risk factors include advanced age, high diastolic and systolic blood pressure, history of renal function damage, ST segment elevation ACS, high blood uric acid level, and emergency PCI. Key words: Acute coronary syndrome; Hypertension; Percutaneous coronary intervention; Renal function; Risk factor