Change of inflammatory factors serum IL–6 and CRP in cognitive impairment in older chronic renal failure patients

Abstract

Objectives To investigate the diversity of serum IL–6 and CRP in older chronic renal failure(CRF) patients with cognitive impairment. Methods 45 older CRF patients were enrolled in this study. (Mini–mental state examination MMSE)were performed. The objects were divided into cognitive damage group and normalcognitive function group according to the presence or absent of cognitive impairment.Serum interleukin–6(IL–6) and creative protein(CRP) were measured as markers of chronic inflammation. Creatinine(Cr), Hemoglobin(Hb), Parathyroid Hormone(PTH), Creatinine clearance rate(Ccr) and other biochemical indicators were also measured in all subjects. Results IL–6 and CRP levels in the cognitive damage group were higher than that in nomal cognitive function group, and there were significant differences (P<0.05); Age, CRF course, Cr, Hb, PTH, Ccr were significant different in two groups(P<0.05); The IL–6 levels of patients were negatively correlated with the score of MMSE. Conclusions There is high prevalence of cognitive impairment in older CRF patients and inflammation is associated with cognitive impairment in older CRF patients. Key words: Kidney Failure, Chronic; Cognition Disorders; Interleukin–6; C–Reactive Protein