Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in lung adenocarcinoma

Abstract

Objective To investigate the correlations of CMTM7 expression and survival rate in patients with lung adenocarcinoma. Methods Surgical specimens of 127 cases with pathologically confirmed lung adenocarcinoma of thoracic surgery were conducted into 18 tissue microarray slides. CMTM7 expression in these specimens was detected by immunohistochemistry staining and then confirmed by Western Blot in represented cases. Univariate and multivariate analyses were performed to identify the association of CMTM7 expression with clinicalpathological features and survival of patients with NSCLC. Results 76.4% of all 127 patients were involved in the variation of CMTM7 protein expression, either up-regulated or down-regulated. Univariate analysis showed that survival after surgery was highly related with CMTM7 expression(P=0.0137). In addition, prognostic factors were examined with multivariate Cox regression analysis, and results suggest the state of CMTM7 expression was the unique prognostic factor in NSCLC survival. Conclusion The state of CMTM7 expression is related to survival of patients with lung adenocarcinoma, and is the unique prognostic factor. CMTM7 may play an important role in lung adenocarcinoma development. Key words: CMTM7 protein, human; Genes, tumor suppressor; Adenocarcinoma; Survival