Change in the dynamics of the catalytic action of azathioprine on the electroreduction process of Bi(III) ions under the influence of surfactants in the context of controlled drug release

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The influence of mixed adsorption layers of azathioprine – Tween 80 as well as azathioprine – Triton X-100 on the multi-step process of Bi(III) electroreduction in chlorates(VII) was studied using EIS and other electrochemical methods. It has been shown that there is control of multistage process of electroreduction of Bi(III) ions through the chemical reaction of the formation of Bi - AZA active complexes on the electrode surface, which mediate electron transfer. Active complexes are a substrate in the process of electroreduction and their different structure and properties are the reason for the diverse catalytic activity of azathioprine. On the other hand, the Bi(III) ions electroreduction process becomes slower in the presence of mixed adsorption layers, because the surfactant molecules block the electrode surface.