Change in the content of glutamate and γ-aminobutyric acid in the subretinal fluid in patients with retinal detachment

Abstract

Obieetive To explore the relation between proliferative vitreous retinopathy after retinal detachment and Glu and GABA.Methods Patients were divided into the control group,non-PVR Group and the PVR group.The content of glutamate and Y-aminobutyric acid in the subretinal fluid (the vitreous for the control group)and blood were quantitatively detected using high pressure liquid chromatography.Results The differences of glutamate and Y-aminobutyric acid in the blood between the patients with retinal detachment and the control patients was not statistically significant.The content of glutamate in the subretinal fluid of patients with retinal detachment was higher than that in the vitreous of control patients,and the content of glutamate in the subretinal fluid of patients with proliferative vitreous retinopathy was higher than that of patients with non-proliferative vitreous retinopathy.The differences were statistically significant(F = 14.031,P ＜0.001).The content of Y-aminobutyric acid in the subretinal fluid of patients with retinal detachment was higher than that in the vitreous of control patients,and the content of Y-aminobutyric acid in the subretinal fluid of patients with proliferative vitreous retinopathy was higher than that of patients with non-proliferative vitreous retinopathy.The differences were statistically significant (F = 9.311,P = 0.001).The rate of glutamate and Y-aminobutyric acid in the subretinal fluid of patients with retinal detachment was higher than that in the vitreous of control patients,and the rate of glutamate and Y-aminobutyric acid in the subretinal fluid of patients with proliferative vitreous retinopathy was higher than that of patients with non-proliferative vitreous retinopathy.The differences were statistically significat(F = 4.411,P = 0.022).Conelussion The content of Y-aminobutyric acid in the subretinal fluid is not sufficient to antagonize the glutamate toxic effect in patients with retinal detachment,especial in patients with proliferative vitreous retiopathy,resulting in transmission functional disturbance of retinal neurons which affects the patients' visual function. Key words: Retinal detachment; Proliferative vitreous retinopathy; Glutamate ; Y-aminobutyric acid