Change in Serum Chloride and Its Relation to Acute Kidney Injury in Septic Shock Patients

Abstract

Abstract Background Septic shock is a dysregulated host response to infection resulting in potentially lifethreatening organ dysfunction. Acute kidney injury (AKI) id one of the most common and serious complications associated with septic shock patients especially in intensive care units. Aim of the Work To evaluate the predictive value of change in serum chloride and its relation to acute kidney injury in septic shock patients. Patients and Methods The study was included 65 septic patients who admitted to intensive care units of Ain Shams University Hospitals, Cairo, Egypt. All the included cases were subjected to full history taking and full general and local examination. Full laboratory investigations were taken from all the cases. The following were done; GCS, SOFA and APACHE II score. The initial serum chloride level and the highest level of chloride during stay was recorded with calculation the difference as the change of serum chloride level. Results In our study, diabetes was the most common comorbidity in the included cases (49 cases – 75.4%), followed by hypertension (40 cases – 61.5%), chest infection was the commonest source of sepsis in our study (33 cases – 50.8%), followed by UTI (23 cases – 35.4%). Other causes included intra-abdominal infections, skin and soft tissue infections and blood stream sepsis. Conclusion Acute kidney injury is a frequent complication in septic patients and optimization of fluid management is fundamental in order to limit the detrimental role of fluids on renal metabolism.