Abstract
Objectives: We wanted to find out the change and pattern of hematological disturbances in patients suffering from malaria and whether the hematological disturbances had any correlation with morbidity in them.Materials and methods: In a retrospective, observational study, first 100 admitted malaria patients in a tertiary medical institute in Kolkata, was taken from August 2009 to July 2011 and their demographic, clinical and laboratorial records were noted and analysed.Results: Seventy-one patients (71%) had anemia, ninety patients (90%) had thrombocytopenia, twenty-six patients (26%) had leucopenia and two patients (2%) had leukocytosis. Vivax malaria patients had lower platelet count than their falciparum counterparts, whereas falciparum malaria patients had lower hemoglobin, packed cell volume and higher total leukocyte count; all these hematological disturbances were found to be correlated with higher morbidity in patients suffering from malaria.Conclusion: In patients suffering from malaria, there was high incidence of hematological disturbances which was changing pattern and also correlated with morbidity.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.403-408
Highlights
Malaria is a vector-bourne disease where malaria parasites infect red blood cells
Various literatures had mentioned about hematological abnormalities present in patients suffering from malaria, namely anemia, leucopenia and thrombocytopenia of varying grade, discussed below
There was no significant difference in reticulocyte count between patients suffering from vivax and falciparum malaria
Summary
Malaria is a vector-bourne disease where malaria parasites infect red blood cells. Eventually in the course of the disease, the malaria parasites lyse the red blood cells and become free to infect other red blood cells. Patients suffering from falciparum malaria had median leukocyte count 1400 per micro litre higher than their vivax counterparts (6100 ± 2882 per micro litre vs 4700 ± 1808 per micro litre, p = 0.01). Median platelet count was lower in patients suffering from vivax malaria by 46500 per micro litre than their falciparum counterparts (76000 ± 35683 per micro litre vs 122500 ± 53135 per micro litre, p < 0.0001).
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