Abstract
The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging [MRI] and Pittsburgh Compound B-positron emission tomography [PiB-PET] measures) during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (post-hoc analyses). FINGER targeted at-risk older adults, aged 60–77 years, from the general population. Participants were randomized to either multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice). Neuroimaging (MRI and PiB-PET) data from baseline and 2-year visits were used. A toal of 112 participants had repeated brain MRI measures (hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer’s disease signature cortical thickness). Repeated PiB-PET scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention was associated with less decline in hippocampus volume in the intervention group, but not the control group (Randomization group × CAIDE change interaction β coefficient = −0.40, p = .02). Associations for other neuroimaging measures were not significant. The intervention may have benefits on hippocampal volume in individuals who succeed in improving their overall risk level as indicated by a reduction in CAIDE score. This exploratory finding requires further testing and validation in larger studies.
Highlights
Recent advances in the field of dementia prevention have highlighted the importance of modifiable risk factors [1]
This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
Characteristics of the FINGER participants with 2 magnetic resonance imaging (MRI) or positron emission tomography (PET) scans are presented in Tables 2 and 3
Summary
Recent advances in the field of dementia prevention have highlighted the importance of modifiable risk factors [1]. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Risk Score was the first midlife prediction tool combining nonmodifiable and modifiable factors. It consists of age, education, blood pressure, cholesterol, body mass index (BMI), and physical activity, and based on the midlife risk profile, it provides a 20-year dementia risk estimate [4]. From a prevention potential perspective, the CAIDE score seemed to work well as a potential surrogate outcome in multidomain lifestyle trials when assessing intervention effects on change in overall dementia risk [14]. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment And Disability (FINGER) is the first large, longer-term randomized controlled trial to show significant benefits on cognition for a 2-year multidomain lifestyle intervention in older individuals at risk of dementia [15]. The aim of the present study was to investigate associations between the change in CAIDE score and changes in brain volumes, cortical thickness, and WML volume on magnetic resonance imaging (MRI), and brain amyloid load on Pittsburgh Compound B (PiB)-positron emission tomography (PET) scans during the 2-year FINGER trial (post-hoc analyses)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
