Abstract
SUMMARY A method is presented for detecting change in biological multivariate stationary processes of a single subject after stimulation. A finite multivariate autoregression is fitted to pre-stimulus data using a step-wise procedure with tests of significance. The fit of the model is also checked by comparing the estimated spectra, phase, and coherence with fitted curves. The statistic which tests for change at a given time point is a quadratic form involving the one-step prediction error vector ancd the inverse of the one-step prediction error covariance matrix. Under the hypothesis of no change, and for a Gaussian process, these statistics have independent chi-square distributions. The technilque has been applied to the detection of change in the brain waves of two human newborn infant's following stimulation.
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