Abstract
The present study was undertaken in order to evaluate the possible mechanisms of action involved in the hypoglycaemic activity of the aqueous extract of Chamaemelum nobile (CN) (20 mg kg-1). This study was carried out in multi low-dose streptozotocin-induced (MLDS) diabetic mice. Hypoglycaemic effect of CN was studied after both single and repeated oral administration of CN aqueous extract (20 mg kg-1). Endogenous glucose production was estimated using primed-continuous 3-3H glucose infusion technique. While, euglycemic hyperinsulinemic glucose clamp technique was used to assess peripheral insulin sensitivity. Both single and repeated oral administration (s) of aqueous CN extract evoked a prominent hypoglycaemic activity in MLDS diabetic mice. In other hand, 3-3H glucose infusion demonstrated that this hypoglycaemic activity was accompanied by a decrease in basal endogenous glucose production (EGP). EGP was lower in CS-treated group when compared to the control group, 15.5±0.5 vs 27.2±7.1 mg kg-1 min-1 (p
Highlights
Diabetes mellitus is a complex metabolic disorder that is increasing tremendously all over the world
The present study was undertaken in order to investigate the hypoglycaemic Induction of diabetes: Diabetes was induced in adult activity of the oral administration of the aqueous extract of Chamaemelum nobile (CN) aerial part and to investigate the possible beneficial effect the intravenous infusion of CN extract fasted male C57BL/6J mice by repeated intraperitoneal injection of streptozotocin (80 mg kg−1) for four consecutive days
The present study was designed to investigate the hypoglycaemic activity of the aqueous extract of Chamaemelum nobile (CN) and to evaluate the possible beneficial effect of CN infusion on hepatic glucose production and whole body insulin sensitivity in multi-low dose streptozotocin-induced diabetic mice
Summary
Diabetes mellitus is a complex metabolic disorder that is increasing tremendously all over the world. Thiazolinediones, are the only available drugs that reduce insulin resistance in peripheral tissues by either mimicking or enhancing insulin action without affecting β-cells insulin secreting capacity[8] These therapies can control many aspects of diabetes, numerous complications are common incidents of the disease and the mortality index due to this illness continue to increase. The present study was undertaken in order to investigate the hypoglycaemic Induction of diabetes: Diabetes was induced in adult activity of the oral administration of the aqueous extract of CN aerial part and to investigate the possible beneficial effect the intravenous infusion of CN extract fasted male C57BL/6J mice by repeated intraperitoneal injection of streptozotocin (80 mg kg−1) for four consecutive days.
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