Abstract
BackgroundReactivation of human herpesvirus 6 (HHV-6) occurs frequently in patients after allogeneic stem cell transplantation and is associated with bone-marrow suppression, enteritis, pneumonitis, pericarditis and also encephalitis. After autologous stem cell transplantation or intensive polychemotherapy HHV-6 reactivation is rarely reported.Case reportThis case demonstrates a severe symptomatic HHV-6 infection with encephalitis and pneumonitis after autologous stem cell transplantation of a patient with relapsed Hodgkin's disease.ConclusionCareful diagnostic work up in patients with severe complications after autologous stem cell transplantation is mandatory to identify uncommon infections.
Highlights
Reactivation of human herpesvirus 6 (HHV-6) occurs frequently in patients after allogeneic stem cell transplantation and is associated with bone-marrow suppression, enteritis, pneumonitis, pericarditis and encephalitis
Diagnosis of HHV6 Infection remains basically PCRbased with detection of viral DNA in blood, cerebrospinal fluid and bronchoalveolar lavage [10]
We report an extremely uncommon infectious complication in a patient with relapsed Hodgkin's disease
Summary
Reactivation of human herpesvirus 6 (HHV-6) occurs frequently in patients after allogeneic stem cell transplantation and is associated with bone-marrow suppression, enteritis, pneumonitis, pericarditis and encephalitis. In patients receiving allogeneic stem cell transplantation reactivations are frequently reported [1-3]. Several reports showed a broad variety of clinical manifestation, ranging from asymptomatic reactivation, delayed hematopoietic recovery up to severe systemic infection with pneumonia and encephalitis [4-8].
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