Abstract
Genus Streptomyces is gram-positive bacteria that grow in various environments. It has plentiful biotechnological attributes on the area of agricultural, bioremediation, biofuel, clinical, food, industrial, medical, pharmaceutical, and veterinary. The aim of the review is to frontward challenges to explore potent Streptomyces species in the case of Ethiopia. There is lack of the extent and quality of the genetic research regarding to genome sequence, bioactive compound discovery, and genetic manipulation. Their functional and structural diversity is not full studied. To find a new Streptomyces species: Culture media formulation and optimization as wells culture-independent method like Next Generation Sequencing approach should incorporate at national level.
Highlights
Genus Streptomyces is gram-positive bacteria that grow in various environmental conditions
The resistance of M. tuberculosis for antituberculosis drugs ranges from 0% up to 32.6%
There is lack of the extent and quality of the genetic research regarding to genome sequence, bioactive compound discovery, and genetic manipulation
Summary
Genus Streptomyces is gram-positive bacteria that grow in various environmental conditions. It found inside plant tissue as endophytic form of life [1] and soil samples [2]. Streptomyces represents the largest taxonomic group within the bacteria domain which is ubiquitously distributed in both aquatic and terrestrial ecosystems [3]. The genus Streptomyces is the most prominent family Streptomycetaceae (order Actinomycetales), which comprises more than 700 species. They are Gram-positive, neutrophilic, facultative aerobic, mesophilic filamentous bacteria, with a growth temperature between 25 and 35°C, whose DNA has a G + C content higher than 70% [4]
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