Abstract
Malondialdehyde is a marker of lipid peroxidation and redox signaling and is used in many researches in the field of plant and biomedical investigations, possibly due to its simple measurement procedure. However, there are some challenges with its measurements which have been discussed in this communication along with possible solutions.
Highlights
Malondialdehyde (MDA) is used as a marker of lipid peroxidation and redox signaling in the field of plant physiology and is one of the commonly used biomarkers of oxidative stress in biomedical and animal studies [1,2,3]
Beside some pitfalls of MDA determination, it is interesting that the number of publications retrieved from Scopus using key words of “malondialdehyde” and “plant*” was increased from 9000 [4] to 13696 records with the numbers of 1304, 1574 and 1094 for years 2018, 2019 and 2020, respectively
The corresponding numbers of articles for key word of “malondialdehyde” are 4643, 5254 and 4028, in which 1525, 1579 and 1137 of the articles categorized in the subject area of “medicine”, respectively for years 2018, 2019 and 2020
Summary
Malondialdehyde (MDA) is used as a marker of lipid peroxidation and redox signaling in the field of plant physiology and is one of the commonly used biomarkers of oxidative stress in biomedical and animal studies [1,2,3]. Different analytical methods have been used for quantification of MDA in biomedical [6] and plant [4] samples. MDA is usually quantified using a simple spectrophotometric, spectrofluorometricand/or enzyme linked immunosorbent assay after derivatization with thiobarbitoric acid (TBA) at a high temperature (90-100 °C) and in acidic solutions [7,8,9].
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