Abstract
Prader–Willi syndrome (PWS) is a rare multisystem genetic disorder and one of the syndromic causes of childhood obesity. It is characterized by learning difficulties and behavioral challenges with subsequent multiple endocrine and multisystem involvement. Congenital leptin deficiency is also a very rare disorder that causes early-onset obesity with hormonal and metabolic disturbances. In this report, we describe the case of an 11- year- old girl who presented to us with uncontrolled blood sugar, significant weight gain, behavioral disturbances and was diagnosed with PWS with congenital leptin deficiency, type 2 diabetes mellitus, hypothyroidism, hypertension and obstructive sleep apnea. The main purpose of this case report is to describe the barriers of glycemic control and lifestyle modification challenges and implement the optimal management plan in such a rare association.
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