Abstract
Patients with cancer are at increased risk of SARA-CoV-2 infection or developing severe COVID-19 cases due to the malignancy or immunosuppressive therapy, but they are generally excluded from the target population for COVID-19 vaccination. In general, inactivated vaccines are safe and immunogenic for patients with cancer, but live attenuated vaccines are not recommended. The study suggested that the safety of the mRNA COVID-19 vaccine in cancer patients is similar to that in healthy people, but the immunogenicity is slightly weaker, and a booster dose may be needed. This paper aims to summarize the results of COVID-19 vaccine clinical studies conducted in cancer patients worldwide and the relevant guidelines released by authorities, so as to provide evidence for promoting COVID-19 vaccination for cancer patients.
Highlights
Cancer is a complex disease which impacts patients including those with active disease, on anticancer treatment, with chronic disease after treatment, or cancer survivors[1]
A number of studies around the world have reported that COVID-19 patients with cancer develop a higher risk for severe disease and case fatality rate from SARS
A prospective observational study in the UK including 800 symptomatic COVID-19 patients with cancer observed no significant difference in the mortality for the patients with chemotherapy and patients with other anticancer treatment[8], and Chinese patients in the early period epidemic who undergone only radiotherapy did not demonstrate higher incidence of severe events compared with patients without cancer[9]
Summary
Corresponding authors: Fengcai Zhu, Jiangsu Provincial Center for Disease Control and Prevention, 172. Potential conflicts of interest: No potential conflicts of interest were disclosed. NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center. Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, ce
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