Abstract
Central precocious puberty (CPP) results from an early activation of the hypothalamic-pituitary-gonadal (HPG) axis (,). The causes of CPP are heterogeneous, with central nervous system abnormalities being of special interest in boys, while idiopathic etiology is more prevalent among girls (). In the last decade, however, the number of idiopathic cases has diminished thanks to the discovery of mutations in different genes, including KISS1, KISS1R, MKRN3 , and DLK1 (,). GnRH analogs (GnRHa) are the mainstay of treatment for this [...]
Highlights
GnRH analogs (GnRHa) are the mainstay of treatment for this endocrine pediatric condition (4,5)
In a prospective study published in this issue of AE&M, Yüce O and cols. (6) showed that first-voided urinary LH measurement was useful to assess pubertal suppression throughout GnRHa treatment in children with Central precocious puberty (CPP)
The authors demonstrated that urinary LH levels were significantly different among patients with adequate and inadequate hormonal suppression in response to GnRHa treatment
Summary
GnRH analogs (GnRHa) are the mainstay of treatment for this endocrine pediatric condition (4,5). In a prospective study published in this issue of AE&M, Yüce O and cols. (6) showed that first-voided urinary LH measurement was useful to assess pubertal suppression throughout GnRHa treatment in children with CPP.
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