Abstract

Coronavirus (COVID-19) is highly infectious agent that causes fatal respiratory illnesses, which is of great global public health concern. Currently, there is no effective vaccine for tackling this COVID19 pandemic where disease countermeasures rely upon preventing or slowing person-to-person transmission. Specifically, there is increasing efforts to prevent or reduce transmission to front-line healthcare workers (HCW). However, there is growing international concern regarding the shortage in supply chain of critical one-time-use personal and protective equipment (PPE). PPE are heat sensitive and are not, by their manufacturer's design, intended for reprocessing. Most conventional sterilization technologies used in hospitals, or in terminal medical device sterilization providers, cannot effectively reprocess PPE due to the nature and severity of sterilization modalities. Contingency planning for PPE stock shortage is important. Solutions in the Republic of Ireland include use of smart communication channels to improve supply chain, bespoke production of PPE to meets gaps, along with least preferred option, use of sterilization or high-level disinfection for PPE reprocessing. Reprocessing PPE must consider material composition, functionality post treatment, along with appropriate disinfection. Following original manufacturer of PPE and regulatory guidance is important. Technologies deployed in the US, and for deployment in the Republic of Ireland, are eco-friendly, namely vaporised hydrogen peroxide (VH2O2), such as for filtering facepiece respirators and UV irradiation and High-level liquid disinfection (Actichlor+) is also been pursed in Ireland. Safeguarding supply chain of PPE will sustain vital healthcare provision and will help reduce mortality.

Highlights

  • Coronaviruses (CoVs) are enveloped viruses with a positive sense, single-stranded RNA genome (Schoeman and Fielding, 2019)

  • The first number of cases were identified in Wuhan, a large city of 11 million people in central China in December 2019, which were linked to the Huanan (Southern China) Seafood Wholesale Market (Rothan and Byrareddy, 2020)

  • These were identified by local hospitals using a surveillance mechanism for “pneumonia of unknown etiology”, which was established in the wake of the 2003 severe acute respiratory syndrome (SARS) outbreak with the aim of allowing timely identification of novel pathogens such as 2019-nCoV (Li et al, 2020)

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Summary

Introduction

Coronaviruses (CoVs) (order Nidovirales, family Coronaviridae, subfamily Coronavirinae) are enveloped viruses with a positive sense, single-stranded RNA genome (Schoeman and Fielding, 2019). A new team of experts was formed (designated REA-PPE) to deploy effective solutions in a short time frame, which included those from across academia, healthcare, Enterprise Ireland-funded technology gateways, Science-Foundation-Ireland (SFI)-funded Research Centres (CURAM for Medical Device, COMMAND for software) and industry.

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