Abstract
Non-classical herbal formulations have gained momentum in the recent past. These formulations, however, have not been well integrated with the modern system of medicine in most of the countries in the world. This is due to the lack of enough scientific evidence pertaining to its long-term safety and efficacy. Besides, the paucity of authentic monographs on the impurity profiling, standardization protocols, lack of guideline on the fixed-dose combinations and absence of programmed pharmacovigilance plan for herbal drugs are among the major caveats. In recent years, few issues pertaining to the classical herbal formulations are being addressed to some extent. However, the issues on non-classical modern formulations remain the same. Hence, the objective of this mini-review is to shed light on the major flaws and challenges of these formulations and provide some expert opinion to counter these issues.
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