Challenge models to study the effect of immune system activation on amino acid metabolism in pigs

E. van de Kampman-Hoek,H. van Beers,J. J. G. C. van den Borne,W. J. J. Gerrits,C. M. C. van der Peet-Schwering,A. J. M. Jansman

doi:10.3920/978-90-8686-781-3_76

Challenge models to study the effect of immune system activation on amino acid metabolism in pigs

E. van de Kampman-Hoek, H. van Beers + Show 4 more

https://doi.org/10.3920/978-90-8686-781-3_76

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Publication Date: Jan 1, 2013

Citations: 2

Affiliation: Wageningen University & Research, Koninklijke Nederlandse Maatschappij voor Diergeneeskunde

#Effect Of Immune System Activation #Production Of Acute Phase Proteins + Show 8 more

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Abstract

In response to (non-)pathogenic challenges, the immune system of pigs can be activated. During immune system activation, there is a competition for amino acids (AA) between body protein deposition (growth) and immune function (Sandberg et al., 2007). As a consequence, feed intake and growth are impaired (Williams et al., 1997) and body protein degradation increases to release AA, e.g. for the production of acute phase proteins (APP) (Reeds et al., 1994). Knowledge about the impact of immune system activation on AA metabolism of pigs is limited. The aim of the present study was to compare the use of Complete Freund’s Adjuvant (CFA) and turpentine oil (TO) to activate the immune system and to study the effect of immune system activation on AA metabolism in pigs.

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