Abstract
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.
Highlights
Cancer is characterized by uncontrolled cell proliferation, which results from accumulated mutations in the DNA of the cells
Chalcones showed pronounced inhibitory activity both cell lines, a higher sensitivity was observed for the BT-20 cells (Table for both cell lines, a higher sensitivity was observed for the BT-20 cells (Table 1)
It can be concluded that trans-chalcone and Licochalcone A reduce cell viability, migration, and invasion in breast cancer cell lines
Summary
Cancer is characterized by uncontrolled cell proliferation, which results from accumulated mutations in the DNA of the cells. Among different types of cancer, breast cancer is the most common cancer in women worldwide, contributing nearly 29% of all cases and showing high mortality rates [1,2,3]. Metastasis is characterized by the ability of cancer cells to invade adjacent or distant tissues, developing secondary tumors. It is responsible for about 90% of cancer-related deaths. The main sites of breast cancer metastasis are the brain, bones, kidneys and lung [4,5]. Metastasis is accountable for the high mortality rates in cancer patients, this process has not yet been completely elucidated. It is known that some genes are related to this process, such as the Aurora Kinase
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
