Abstract

It is shown that the action of acetic acid on 2′-acetoxy-4,6′-dimethoxychalcone dibromide results in deacetylation, debromination of the side-chain, and nuclear halogenation rather than in elimination of hydrogen bromide to form an α-bromochalcone. The generality of the dehalogenation of the α,β-dibromo ketone in acetic acid and its relation to the ortho steric effect are discussed.

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