Abstract

AbstractTwo new coordination complexes were synthesized, which are formulated as [Cu2(cis‐1,4‐chdc)(4,4′‐Me2bpy)4] ⋅ 2(ClO4−) ⋅ H2O (1) and [Cu2(cis‐1,4‐chdc)(5,5′‐Me2bpy)4] ⋅ 2(ClO4−) ⋅ H2O (2), using cis‐1,4‐cyclohexanedicarboxylic acid (cis‐1,4‐H2chdc), 4,4′‐dimethyl‐2,2′‐bipyridine (4,4′‐Me2bpy), 5,5′‐dimethyl‐2,2′‐bipyridine (5,5′‐Me2bpy). Interestingly, cis‐1,4‐chdc adopts chair form in 1 and boat conformation in 2. This conformational change impacts the DNA binding capacities of the complexes as revealed by spectrophotometry, circular dichroism (CD) spectroscopy and docking studies. The complex 1 having the chair conformation shows higher affinity towards the DNA base pairs due to anti‐alignment of the planar aromatic pyridyl rings of 4,4′‐Me2bpy, which strongly intercalates with the adenosine base pairs of DNA by formation of three π–π stacking and two extra π‐positive stacking interactions between adenosine bases and positively charged nitrogen. Conversely, 5,5′‐Me2bpy with planar aromatic pyridyl rings of complex 2 shows bis‐intercalation with weak affinities toward base pairs by formation of two π–π stacking and one π‐positive stacking interactions.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.