Abstract
Chitosans with different chemical compositions ( F A = 0.05–0.65) and different molecular weights ( M w = 36.000–460.000) were studied by size-exclusion chromatography combined with multi-angle laser light scattering (MALS) and viscosity detectors to provide R G– M and [ η]– M data as basis for further analysis using the wormlike chain model. In both cases intrinsic persistence lengths ( q 0) in the range 5.1–7.6 nm were obtained, with little or no detectable dependence on F A. These values are significantly lower than values obtained for alginates (12 nm), including homopolymeric mannuronan, using the same approach. This finding is also corroborated by differences in the Smidsrød B-parameter, confirming that chitosans are less extended than alginates, despite the similarity in basic chain geometry (cellulose type) and linear charge density. Partial periodate oxidation of chitosans led to a pronounced increase in the chain flexibility as shown by a gradual decrease in persistence length, approaching 2 nm for the most oxidised samples.
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