Abstract
Abstract Chronic Chagas disease cardiomyopathy (CCC) is a result of low-intensity, but incessant, focal fibrosing myocarditis, caused by persistent T. cruzi infection associated with inflammation, mediated by adverse immune mechanisms. About 30 percent of infected individuals have developed throughout life the chronic cardiac form of Chagas’ disease with protean clinical manifestations, such as sudden death, signs and symptoms of heart failure, cardioembolic events, arrhythmia and angioid symptoms. Sudden death and the progression of heart failure (HF) are the most common [...]
Highlights
Chagas disease (ChD) is caused by the protozoan parasite Trypanosoma cruzi, which causes an acute myocarditis and subsequently a low-grade incessant chronic fibrosing myocarditis, which produces progressive myocardial damage and later results in chronic cardiomyopathy of chronic Chagas' disease (CCC)
The symptoms and physical signs present in the chronic phase of the Chagas disease cardiomyopathy are a result of four essential syndromes that can often coexist in the same patient: heart failure, arrhythmias, thromboembolism and anginal manifestations
The results indicate that chronically T. cruzi infected patients, when compared to the non-infected, had an excess risk of stroke of about 70% (RR = 1.70; heart failure (HF) 95%: 1.06 to 2.71)
Summary
Marcus Vinicius Simões, Minna Moreira Dias Romano, André Schmidt, Káryta Suely Macedo Martins, José Antonio Marin-Neto. Divisão de Cardiologia - Departamento de Clínica Médica - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, SP – Brazil
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