Abstract
To date, there is no effective pharmacologic treatment for Chagas' cardioneuropathy, one of the most common causes of congestive heart failure and sudden death in the world. Fifty-eight adults with positive serology for Chagas' disease and abnormal autonomic nervous system tests participated in this placebo-controlled clinical trial with Cronassial (mixed gangliosides), 40 mg daily intramuscular injection for 4 or 8 weeks. We measured postural response (heart rate, systolic and diastolic arterial blood pressure changes in response to standing); heart rate changes induced by cough and hyperventilation reflex tests; dizziness on standing; number of stress-induced arrhythmias; and periodic acid-Schiff (PAS)-positive T-lymphocyte percentage in blood samples. Cronassial is safe and significantly improves systolic blood pressure ( p = 0.050) and double product responses to postural stress ( p = 0.028), hyperventilation heart rate response ( p = 0.007), frequency of dizziness episodes ( p < 0.001), number of arrhythmias ( p = 0.033), and percentage of PAS-positive T-lymphocyte counts ( p < 0.001) compared with placebo.
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