Abstract
A marine fungal isolate, identified as Chaetomium sp., was cultivated and found to produce a novel benzonaphthyridinedione derivative, chaetominedione ( 1). In addition to the known fungal metabolites, 2-furancarboxylic acid ( 2) and 5-(hydroxymethyl)-2-furancarboxylic acid ( 3) were obtained. The structures of all the compounds were determined based on extensive spectroscopic measurements (1D and 2D NMR, MS, UV, and IR). The total extract and compound 1 had significant inhibitory activity toward p56 lck tyrosine kinase (18.7% and 93.6% enzyme inhibition at 200 μg/mL, respectively).
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