Abstract
Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected.
Highlights
Fungi of the Chaetomium species are the largest genus of saprophytic ascomycetes, which belongs to the Chaetomiaceae family
Until now more than 200 compounds with a wide range of bioactive effects have been isolated from Chaetomium spp., but compared with its richness of species, more bioactive secondary metabolites might be found in this member of fungi [3]
We reported the isolation from Chaetomium indicum (CBS.860.68) of two new polyketides, chaetochromones A (1) and B (2), along with the three known analogues PI-3 (3), PI-4 (4), and SB236050 (5)
Summary
Fungi of the Chaetomium species are the largest genus of saprophytic ascomycetes, which belongs to the Chaetomiaceae family. Chaetomium species have been described [1] This fungal spp. is widely distributed in different biotopes, such as soils, marine, animal dung, hair, textiles, plant seeds and some other substrates rich in cellulose. Until now more than 200 compounds with a wide range of bioactive effects have been isolated from Chaetomium spp., but compared with its richness of species, more bioactive secondary metabolites might be found in this member of fungi [3]. Chaetomium indicum (CBS.860.68) together with three known analogues PI-3 (3) [6], PI-4 (4) [6] and SB236050 (5) [7] (Figure 1) These secondary metabolites displayed different degrees of inhibitory activity against eight plant pathogens. We will present the structure elucidation and bioactive evaluation, and postulate their plausible biosynthesis
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