Abstract
Central- and peripheral-type benzodiazepine receptors were analyzed in several brain areas of rats (n = 8–9) that had been treated for five days with CGS 8216 (20 mg/kg per day). Twenty-four hours after cessation of drug treatment a significant decrease of central-type benzodiazepine receptors as labeled by [ 3H]β-carboline-3-carboxylate ethyl ester ([ 3H]βCCE) and [ 3H]flunitrazepam ([ 3H]FNZ), but not of peripheral-type benzodiazepine receptors as labeled by [ 3H]RO 5-4864 could be observed in the animals treated with CGS 8216.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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